Publications

You can find a list of publications on my Google Scholar page or this National Library of Medicine page. Papers are listed below with some selected data highlights.

2024

Posner, M., T. Garver, T. Kaye, S. Brdicka, M. Suttle, B. Patterson, D.R. Farnsworth. 2024. Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Exp. Eye Res. 109918 PubMed link

The first study to show how loss of specific lens proteins impacts age-related cataract in zebrafish (Figure 4)

2023

Posner, M., K.L. Murray, B. Andrew, S. Brdicka, A. Butterbaugh-Roberts, K. Franklin, A. Hussen, T. Kaye, E. Kepp, M.S. McDonald, T. Snodgrass, K. Zientek, L. David. 2023. Impact of α-crystallin protein loss on zebrafish lens development. Exp Eye Res. 227:109358

We report CRISPR-generated mutants for three lens crystallin protein genes and how protein loss impacts lens development (Figure 2)

2021

Farnsworth, D, M. Posner, A. Miller. 2021. Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Exp Eye Res 108535

The first single-cell gene expression atlas for any vertebrate lens published with collaborator Dr. Dylan Farnsworth (Figure 1)

This analysis identified numerous genes with strong lens expression but no known reported lens function. We are screening these genes with CRISPR editing to explore novel lens development mechanisms (Figure 7)

2019

Posner, M, M.S. McDonald, K.L. Murray, AJ Kiss. 2019. Why does the zebrafish cloche mutant develop cataract? PLOS ONE 14(3): e0211399

2017

Posner, M, K.L. Murray, M.S. McDonald, H. Eighinger, B. Andrew, A. Drossman, Z. Haley, J. Nussbaum, L.L. David, K.J. Lampi. 2017. The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function. PeerJ 5:e4093

2016

Fountain, DI, L. Knapp, K. Baugh, M. Posner, S.D. Fenster. 2016. Piccolo paralogs and orthologs display conserved patterns of splicing within the C2A and C2B domains. Genes and Genomics. 38:407-419

2013

Posner, M., J. Skiba, M. Brown, J. Liang, J. Nussbaum, H. Prior. 2013. Loss of the small heat shock protein αA-crystallin does not lead to detectable defects in early zebrafish lens development. Experimental Eye Research. 116:227-233

Weidenhamer, J.D., M. Li, J. Allman, R.G. Bergosh, M. Posner. 2013. Evidence Does not Support a Role for Gallic Acid in Phragmites australis Invasion Success. Journal of Chemical Ecology. 39:323-332

2012

Posner, M, A.J. Kiss, J. Skiba, A. Drossman, M. Dolinka, J.F. Hejtmancik, Y. Sergeev. 2012. Functional validation of hydrophobic adaptation to physiological temperature in the small heat shock protein αA-crystallin. PLoS One 7(3): E34438

2008

Posner, M., M. Hawke, C. LaCava, C. Prince, N.R Bellanco, R.W. Corbin. 2008. A proteome map of the zebrafish (Danio rerio) lens reveals similarities between zebrafish and mammalian crystallin expression. Molecular Vision. 14:806-814

2006

Smith, A.A., K. Wyatt, J. Vacha, T.S. Vihtelic, J.S. Zigler, G.J. Wistow, M. Posner. 2006. Gene duplication and separation of functions in alpha B-crystallin from zebrafish (Danio rerio). FEBS Journal. 273:481-490

2005

Dahlman, J., K. Margot, L-L. Ding, J. Horwitz and M. Posner. 2005.Zebrafish alpha crystallins: protein structure and chaperone-like activity compared to their mammalian orthologs. Molecular Vision. 11:88-96

2003

Posner, M. 2003. A comparative view of alpha crystallins: the contribution of comparative studies to understanding function. Integrative and Comparative Biology. 43:481-491

2002

Posner, M. 2002. Linking stress and cell action: review of cell and molecular responses to stress, volume 2: protein adaptations and signal transduction. Journal of Experimental Biology. 205:223-2324

Runkle, S., J. Hill, M. Kantorow, J. Horwitz and M. Posner. 2002. Sequence and spatial expression of zebrafish (Danio rerio) αA-crystallin. Molecular Vision. 8:45-50

1999

Posner, M., M. Kantorow and J. Horwitz. 1999. Cloning, sequencing and differential expression of αB-crystallin in the zebrafish, Danio rerio. Biochimica et Biophysica Acta – Gene Structure and Expression. 1447: 271-277

Posner, M. and R.J. Lavenberg. 1999. Movement of California halibut, Paralichthys californicus, along the coast of California. California Department of Fish and Game. 85: 45-55

Posner, M. and R.J. Lavenberg. 1999. Kasatkia seigeli, a new species of Stichaeid (Perciformes: Stichaeidae) from California. Copeia. 1999(4): 1035-1040